5-Amino-1MQ – High Purity Premium Small Molecule API

Product Overview 5-Amino-1MQ (5-Amino-1-methylquinolinium iodide) is a cell-permeable selective small-molecule inhibitor targeting nicotinamide N-methyltransferase (NNMT). It competitively blocks NNMT catalytic activity, avoids nicotinamide consumption, elevates intracellular NAD? concentration, activates sirtuin family proteins, improves mitochondrial biogenesis and fatty acid oxidation, and effectively regulates adipocyte differentiation and systemic energy metabolism balance. It features high target selectivity, strong membrane permeability and clear metabolic action pathway. It is applied in laboratory research including obesity mechanism exploration, insulin resistance regulation, NAD? salvage pathway study, aging-related metabolic decline and adipose tissue remodeling assays. It is extensively adopted in energy metabolism signaling pathway verification, metabolic syndrome pharmacodynamic testing and small molecule enzyme inhibitor pharmacological evaluation. Adopting optimized chemical synthesis and recrystallization purification technology, the product boasts stable solubility in DMSO and sustained reliable biological activity after reconstitution. CAS Number: 42464-96-0

Technical Specifications & Quality Standards

HPLC Purity: ≥99.0% Identity Test: HPLC verification + NMR structural identification & mass spectrometry detection, molecular weight fully matches theoretical standard value Appearance: Lyophilized light reddish-brown fine powder Strict CQA Quality Control: Full-item detection including residual organic solvents, heavy metal content, bacterial endotoxin, microbiological limits, moisture content and enzyme inhibition activity verification;

The entire production line follows standardized GMP management system, guaranteeing uniform quality among different batches.

Supply & Order Instructions

Production Capacity: Stable large-scale manufacturing available, supporting kilogram-level bulk procurement and small-volume trial sample orders

Lead Time: Bulk kilogram orders need one month advance reservation owing to multi-step synthetic routes and repeated impurity inspection processes; sample orders enjoy shorter delivery cycle.

Quality Assurance

Each shipment batch is attached with a full official Certificate of Analysis (COA). The product maintains purity over 99.0% with intact biological activity; third-party independent laboratory re-inspection is acceptable for purchasers’ authenticity confirmation.

Payment Options

Alibaba Trade Assurance, PayPal, USDT, Bank Wire Transfer, Western Union

Core Advantages

Standard regular packaging: inner glass vial + external plastic box, suitable for long-term sealed storage at -20°C protected from light In-house professional R&D laboratory team, providing customized solvent dilution and specification repackaging service

Confidential worldwide delivery equipped with light-proof low-temperature cold-chain packaging to prevent structural decomposition during transportation