Mazdutide (IBI-362) – High Purity Premium Lipidated Dual-Agonist Peptide API

Product Overview Mazdutide, also known as IBI-362, LY-3305677, is a long-acting lipidated synthetic oxyntomodulin (OXM) analogue and dual agonist of GLP?1R and GCGR receptors. Aib substitution modification resists DPP?4 enzymatic degradation, and C20 fatty diacid side chain enables reversible binding to serum albumin, greatly prolonging in vivo half-life to support once-weekly administration. It activates GLP?1R to stimulate glucose-dependent insulin secretion, suppress glucagon release, slow gastric emptying and curb appetite; meanwhile activates GCGR to boost fat decomposition, elevate whole-body energy expenditure and improve hepatic lipid metabolism, achieving synergistic effects of hypoglycemia, weight loss and liver fat reduction.

It is applied in laboratory research covering type 2 diabetes glycemic regulation, obesity intervention, non-alcoholic fatty liver disease mechanism, energy metabolism remodeling, dual-receptor pharmacodynamic verification and metabolic syndrome studies. It is widely used in metabolic signaling pathway analysis, long-acting peptide pharmacokinetics tests and dual-target agonist pharmacological evaluation experiments.

Adopting optimized solid-phase peptide synthesis, unnatural amino acid substitution and lipidation modification & chromatographic refining technology, the product features good aqueous solubility and stable biological activity after reconstitution with designated solvent. CAS Number: 2259884-03-0

Technical Specifications & Quality Standards

HPLC Purity: ≥99.0% Identity Test: HPLC verification + full mass spectrometry peptide sequencing + lipidation modification rate detection, molecular weight fully matches theoretical standard value Appearance: Aseptic lyophilized white fine powder

Strict CQA Quality Control: Full-item detection including residual organic solvents, heavy metal content, bacterial endotoxin, microbiological limits, peptide sequence integrity and fatty acid coupling rate verification;

The entire production line follows standardized GMP management system to guarantee consistent quality among batches.

Supply & Order Instructions

Production Capacity: Stable large-scale manufacturing available, supporting kilogram-level bulk procurement and small-volume trial sample orders

Lead Time: Bulk kilogram orders require one-month advance reservation due to multi-step synthesis, unnatural amino acid modification and repeated strict impurity inspection processes; sample orders enjoy shorter delivery cycle.

Quality Assurance

Each shipment batch is attached with complete official Certificate of Analysis (COA). The product maintains purity over 99.0% with intact biological activity; third-party independent laboratory re-inspection is acceptable for authenticity confirmation.

Payment Options

Alibaba Trade Assurance, PayPal, USDT, Bank Wire Transfer, Western Union

Core Advantages

Standard vial + outer carton packaging, suitable for long-term light-proof low-temperature sealed storage; In-house professional peptide R&D laboratory team provides customized specification repackaging and concentration dilution service;

Confidential global delivery with dedicated low-temperature cold-chain packaging to avoid peptide structural degradation and lipid side chain shedding during long-distance transportation.