Survodutide (BI 456906) – High Purity Premium Lipidated Dual-Agonist Peptide API

Product Overview Survodutide, R&D code BI 456906, is a long-acting acylated twincretin peptide jointly developed by Boehringer Ingelheim and Zealand Pharma, serving as balanced dual agonist of GLP?1R and GCGR receptors. Consisting of 29 amino acids, Ac4c non-natural amino acid substitution at position 2 effectively prevents degradation by DPP?4 enzyme; coupled C18 fatty diacid side chain reversibly binds serum albumin and greatly prolongs in vivo half-life to support once-weekly administration.

Activation of GLP?1R realizes glucose-dependent insulin secretion promotion, glucagon suppression, delayed gastric emptying and central appetite inhibition to stabilize blood glucose; meanwhile GCGR activation accelerates hepatic fatty acid oxidation, raises whole-body energy expenditure and upregulates FGF21 expression, bringing extra weight loss and hepatic fat clearance effects unavailable to single GLP?1 agonists. It has obtained FDA Breakthrough Therapy Designation for MASH accompanied by liver fibrosis, and completed Phase III clinical trials for obesity and type 2 diabetes mellitus.

It is applied in laboratory research including type 2 diabetes glycemic regulation, obesity intervention, MASH & hepatic fibrosis mechanism study, energy metabolism remodeling, dual-receptor synergistic pharmacodynamic verification and long-acting peptide pharmacokinetic experiments. It is extensively adopted in metabolic signaling pathway exploration and twincretin new drug preclinical evaluation tests.

Adopting optimized solid-phase peptide synthesis, site-specific unnatural amino acid modification and lipidation chromatographic refining technology, the product features excellent water solubility and stable biological activity after reconstitution with designated solvent. CAS Number: 2805997-46-8

Technical Specifications & Quality Standards

HPLC Purity: ≥99.0% Identity Test: HPLC verification + full mass spectrometry peptide sequencing + lipidation modification rate detection, molecular weight fully matches theoretical standard value Appearance: Aseptic lyophilized white fine powder Strict CQA Quality Control: Full-item detection including residual organic solvents, heavy metal content, bacterial endotoxin, microbiological limits, peptide sequence integrity and fatty acid coupling rate verification;

The entire production line follows standardized GMP management system, guaranteeing uniform quality among different batches.

Supply & Order Instructions

Production Capacity: Stable large-scale manufacturing available, supporting kilogram-level bulk procurement and small-volume trial sample orders

Lead Time: Bulk kilogram orders need one month advance reservation owing to multi-step synthesis, site-specific modification and multi-round strict impurity inspection processes; sample orders enjoy shorter delivery cycle.

Quality Assurance

Each shipment batch is attached with a full official Certificate of Analysis (COA). The peptide maintains purity over 99.0% with intact biological activity; third-party independent laboratory re-inspection is acceptable for authenticity confirmation.

Payment Options

Alibaba Trade Assurance, PayPal, USDT, Bank Wire Transfer, Western Union

Core Advantages

Standard regular packaging: inner glass vial + outer carton, suitable for long-term light-proof low-temperature sealed storage In-house professional peptide R&D laboratory team, providing customized specification repackaging and concentration dilution service

Confidential worldwide delivery equipped with dedicated low-temperature cold-chain packaging to avoid peptide structural degradation and lipid side chain shedding during transportation