Thymalin is a low-molecular-weight thymic polypeptide complex extracted from the thymus gland of young calves via mild acid hydrolysis, consisting of a mixture of bioactive short peptides with molecular weight less than 10 kDa. Its core active components include dipeptides Glu-Trp (EW), Lys-Glu (KE) and tripeptide Glu-Asp-Pro (EDP). As a natural peptide bioregulator, Thymalin regulates thymic function and immune homeostasis through epigenetic modulation and immune cell differentiation pathways.
Physicochemical Properties
Appearance: White lyophilized powder
Solubility: Freely soluble in sterile normal saline and water
Peptide Content: ≥80%
HPLC Purity: ≥98%
Moisture: ≤10%
Molecular Weight Range: <10 kDa
Storage Condition: Long-term storage at -20°C, protected from light and moisture; reconstituted solution stable at 2–8°C within 72 hours.
Mechanism of Action
Promotes the maturation and differentiation of T lymphocytes in the thymus, elevates CD3+, CD4+, CD8+ cell counts and normalizes CD4/CD8 ratio to reverse thymic involution and age-related lymphopenia.
Balances pro-inflammatory and anti-inflammatory cytokines: suppresses excessive TNF-α, IL-6 and IL-1β to mitigate cytokine storm; upregulates IL-2 and IFN-γ to enhance specific antigen immune response.
Boosts phagocytic activity of macrophages and neutrophils to strengthen innate immunity against bacterial and viral infections.
Repairs hematopoietic function after chemotherapy and radiotherapy, alleviates myelosuppression and leukopenia.
Exhibits anti-aging geroprotective effects by reducing lymphocyte apoptosis, enhancing DNA repair and inhibiting inflammaging.
Application Scope
This product is strictly for laboratory in vitro testing and animal experimental research only. Not approved for human injection, oral administration or clinical treatment. Common research directions include immunology, anti-aging study, radiochemotherapy auxiliary research and chronic inflammation model establishment.
Specification & Packing
Standard specifications: 1mg/vial, 5mg/vial, 10mg/vial, 100mg/vial