Name: ACE-031

Alias: Myostatin inhibitory peptide 7, ActRIIB-IgG1 fusion protein CAS Registry number: 1621169-52-5 Sequence: Extracellular ligand-binding domain of human activin receptor type IIB fused with human IgG1 Fc segment Molecular Formula: C???H???N??O?? Molecular Weight: 2956.5 Da Purity: ≥99% (by HPLC) Appearance: White lyophilized powder Packing: 10 vials/box Product Group: Peptide

Storage Conditions: Store at -20℃ in a dry, dark place; avoid repeated freeze-thaw cycles.

Brief Introduction:

ACE-031 is a recombinant ActRIIB-IgG1 fusion protein solely for laboratory research use. It acts as a soluble decoy receptor to neutralize myostatin, activin A and GDF-11, blocking TGF-β/SMAD inhibitory signaling to boost skeletal muscle proliferation and hypertrophy. The IgG1 Fc fragment extends circulation half-life for long-term in-vivo model research, widely used in muscle wasting, muscular dystrophy and musculoskeletal metabolic mechanism studies.

1. Skeletal muscle hypertrophy research: Used in myoblast and animal models to study myostatin suppression, muscle fiber enlargement and lean mass growth physiological pathways.
2. Muscle atrophy & myopathy research: Suitable for exploring Duchenne muscular dystrophy, sarcopenia and cachexia intervention mechanisms.
3. TGF-β superfamily signal research: Applied to investigate SMAD2/3 downstream pathway regulation and cross-talk between muscle growth factors.
4. Bone & fat metabolism research: For experiments on bone mineral density improvement and fat mass reduction mediated by ActRIIB blockade.

Note:

This product is for laboratory research use only. It is not intended for human or animal therapeutic use, clinical trials, or any form of in vivo administration without prior ethical approval and regulatory authorization.