Name: SS-31

Alias: Elamipretide / MTP-131 / Szeto-Schiller 31 Peptide

CAS Registry number: 736992-21-5

Sequence:

D-Arg-Dmt-Lys-Phe-NH? (Dmt = 2,6-dimethyltyrosine)

Molecular Formula: C??H??N?O?

Molecular Weight: 639.79 Da

Purity: ≥99% (by HPLC)

Appearance: White lyophilized powder

Packing: 10 vials/box (10mg & 50mg total per vial optional)

Product Group: Mitochondria-targeted antioxidant peptide

Storage Conditions: Store at -20℃ in a dry, dark place; avoid repeated freeze-thaw cycles.

Brief Introduction:

SS-31 is a synthetic Szeto-Schiller tetrapeptide exclusively for laboratory research. It features unique aromatic-cationic structure that enables selective accumulation in the inner mitochondrial membrane and specific binding to cardiolipin. SS-31 stabilizes mitochondrial cristae structure and electron transport chain, inhibits lipid peroxidation, cuts excess ROS production and restores cellular ATP synthesis. It blocks mitochondrial permeability transition pore to suppress cell apoptosis triggered by oxidation and ischemia, delivering comprehensive protective effects on heart, nerve, skeletal muscle and renal tissues. It is widely adopted for mitochondrial bioenergetics, oxidative injury and age-related degenerative disease research.

Main Research Applications:

Mitochondrial bioenergetics research: Used in cell and animal models to study cardiolipin stabilization, respiratory chain balance and ATP production regulation.

Cardiac ischemia-reperfusion injury research: Suitable for exploring myocardial anti-oxidation, anti-apoptosis and cardiac function recovery mechanisms.

Neurodegeneration & neuroprotection research: Applied to investigate mitochondrial dysfunction mediated neuronal damage, anti-neuroinflammation and brain tissue repair pathways.

Muscle aging & fatigue research: For sarcopenia intervention, exercise endurance improvement and age-related mitochondrial decay analysis.

Renal & retinal oxidative damage research: Comparative analysis of tubular cell and photoreceptor protection against oxidative stress.

Note:

This product is for laboratory research use only. It is not intended for human or animal therapeutic use, clinical trials, or any form of in vivo administration without prior ethical approval and regulatory authorization.