Name: 5-Amino-1MQ

Alias: 5-Amino-1-methylquinolinium iodide / NNMT inhibitor CAS Registry number: 42464-96-0 Sequence: N/A (Small molecule compound) Molecular Formula: C??H??IN? Molecular Weight: 286.11 Da Purity: ≥99% (by HPLC) Appearance: White lyophilized powder Packing: 10 vials/box (10mg total per vial) Product Group: NNMT metabolic inhibitory small molecule

Storage Conditions: Store at -20℃ in a dry, dark place; avoid repeated freeze-thaw cycles.

Brief Introduction:

5-Amino-1MQ is a synthetic selective nicotinamide N-methyltransferase (NNMT) inhibitor exclusively for laboratory research. It effectively blocks NNMT enzymatic activity, reduces nicotinamide methylation consumption, elevates intracellular NAD+ concentration and activates sirtuin signaling pathways. It improves mitochondrial energy metabolism, enhances insulin sensitivity, inhibits adipose accumulation and optimizes systemic metabolic homeostasis. It also participates in epigenetic methylation regulation and cellular anti-senescence processes, widely applied in NAD+ metabolism, obesity mechanism, mitochondrial physiology and metabolic aging research.

Main Research Applications:

NNMT enzyme inhibition research: Used in cell and animal models to study methylation pathway blockage and nicotinamide salvage pathway regulation. NAD+ metabolic research: Suitable for exploring intracellular NAD+ elevation, sirtuin activation and energy production enhancement pathways. Adipose & weight metabolism research: Applied to investigate fat mass reduction, insulin resistance improvement and visceral lipid metabolism regulation. Mitochondrial function research: For comparative analysis of mitochondrial biogenesis promotion and oxidative stress relief effects.

Metabolic aging research: Study metabolic homeostasis remodeling and age-related degenerative disorder intervention characteristics.