Name: PE 22-28

Alias: Optimized Spadin Heptapeptide, TREK-1 Channel Inhibitor CAS Registry number: 1801959-12-5 Sequence: Gly-Val-Ser-Trp-Gly-Leu-Arg-NH? Molecular Formula: C??H??N??O? Molecular Weight: 773.88 Da Purity: ≥99% (by HPLC) Appearance: White lyophilized powder Packing: 10mg*10vials/box Product Group: Mood-regulating neuroprotective heptapeptide

Storage Conditions: Store at -20℃ in a dry, dark place; avoid repeated freeze-thaw cycles.

Brief Introduction:

PE 22-28 is an optimized synthetic seven-amino-acid peptide truncated from natural Spadin, exclusively for laboratory research. It acts as a high-selective TREK-1 two-pore potassium channel inhibitor with IC?? = 0.12 nM, blocking excessive K? outflow to raise neuronal excitability in mood-related brain regions such as hippocampus and raphe nucleusMedChemExp.... It boosts serotonergic signal transmission, accelerates hippocampal neurogenesis and relieves oxidative neuronal damage, showing fast antidepressant and anti-anxiety effects far quicker than traditional SSRIs without long latency periodmyotrope.c.... It also suppresses NF-κB inflammatory pathway, reduces pro-inflammatory cytokines, alleviates cerebral ischemia-reperfusion injury and improves cognitive function under stress, widely applied in mood disorder, neurogenesis, neuroprotection and novel antidepressant pharmacology research.

Main Research Applications:

Depression & anxiety research: Used in cell and animal models to study TREK-1 channel regulation and rapid mood improvement mechanisms. Hippocampal neurogenesis research: Suitable for exploring neural progenitor cell proliferation and synaptic plasticity promotion pathways. Cerebral ischemia protection research: Applied to investigate neuronal anti-apoptosis and brain injury recovery effects. Stress-induced cognitive impairment research: For comparative analysis of stress hormone balance and memory restoration.

Novel antidepressant peptide pharmacology research: Study TREK-1 targeted pathway distinct from serotonin reuptake inhibitors.